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Nzoner's Game Room>***NON-POLITICAL COVID-19 Discussion Thread***
JakeF 10:28 PM 02-26-2020
A couple of reminders...

Originally Posted by Bwana:
Once again, don't come in this thread with some kind of political agenda, or you will be shown the door. If you want to go that route, there is a thread about this in DC.
Originally Posted by Dartgod:
People, there is a lot of good information in this thread, let's try to keep the petty bickering to a minimum.

We all have varying opinions about the impact of this, the numbers, etc. We will all never agree with each other. But we can all keep it civil.

Thanks!

Click here for the original OP:

Spoiler!

[Reply]
notorious 05:19 PM 05-05-2021
Originally Posted by sedated:
I know exactly one person that hasn't gotten at least one vax shot. All friends, family, and everyone in my office have gotten it. Really surprising how quickly everything moved after the initial logjam.
There are a ton of unvaccinated people out here.

Everything is open to full capacity, mask free.

We haven't had a jump in cases. That's just our little slice of America, though. I think it passed through almost everyone around here (huge "immigrant" population, lots of packing plants) and we've built a natural immunity to it.
[Reply]
Discuss Thrower 07:03 PM 05-05-2021
Originally Posted by TLO:
Maybe India should start lobbing nukes at Chy-nuh
Obviously you've never played Civ 3
[Reply]
Stewie 08:56 AM 05-06-2021
2nd Pfizer shot yesterday. Mild aching like the first time. Shoulder pain is more noticeable. Maybe should have gotten it in the arm that didn't get the first one.
[Reply]
MahomesMagic 09:40 AM 05-07-2021
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
Alessandro Sette & Shane Crotty
Nature Reviews Immunology volume

T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses.

As data start to accumulate on the detection and characterization of SARS-CoV-2 T cell responses in humans, a surprising finding has been reported: lymphocytes from 20–50% of unexposed donors display significant reactivity to SARS-CoV-2 antigen peptide pools1,2,3,4.

In a study by Grifoni et al.1, reactivity was detected in 50% of donor blood samples obtained in the USA between 2015 and 2018, before SARS-CoV-2 appeared in the human population. T cell reactivity was highest against proteins other than the coronavirus spike protein, but T cell reactivity was also detected against spike. The SARS-CoV-2 T cell reactivity was mostly associated with CD4+ T cells, with a smaller contribution by CD8+ T cells1. Similarly, in a study of blood donors in the Netherlands, Weiskopf et al.2 detected CD4+ T cell reactivity against SARS-CoV-2 spike peptides in 1 of 10 unexposed subjects and against SARS-CoV-2 non-spike peptides in 2 of 10 unexposed subjects. CD8+ T cell reactivity was observed in 1 of 10 unexposed donors. In a third study, from Germany, Braun et al.3 reported positive T cell responses against spike peptides in 34% of SARS-CoV-2 seronegative healthy donors. Finally, a study of individuals in Singapore, by Le Bert et al.4, reported T cell responses to nucleocapsid protein nsp7 or nsp13 in 50% of subjects with no history of SARS, COVID-19, or contact with patients with SARS or COVID-19. A study by Meckiff using samples from the UK also detected reactivity in unexposed subjects5. Taken together, five studies report evidence of pre-existing T cells that recognize SARS-CoV-2 in a significant fraction of people from diverse geographical locations.

These early reports demonstrate that substantial T cell reactivity exists in many unexposed people; nevertheless, data have not yet demonstrated the source of the T cells or whether they are memory T cells. It has been speculated that the SARS-CoV-2-specific T cells in unexposed individuals might originate from memory T cells derived from exposure to ‘common cold’ coronaviruses (CCCs), such as HCoV-OC43, HCoV-HKU1, HCoV-NL63 and HCoV-229E, which widely circulate in the human population and are responsible for mild self-limiting respiratory symptoms. More than 90% of the human population is seropositive for at least three of the CCCs6. Thiel and colleagues3 reported that the T cell reactivity was highest against a pool of SARS-CoV-2 spike peptides that had homology to CCCs.

What are the implications of these observations? The potential for pre-existing crossreactivity against COVID-19 in a fraction of the human population has led to extensive speculation. Pre-existing T cell immunity to SARS-CoV-2 could be relevant because it could influence COVID-19 disease severity. It is plausible that people with a high level of pre-existing memory CD4+ T cells that recognize SARS-CoV-2 could mount a faster and stronger immune response upon exposure to SARS-CoV-2 and thereby limit disease severity.


https://www.nature.com/articles/s41577-020-0389-z
[Reply]
Discuss Thrower 11:55 AM 05-07-2021
Misinformation. Reported.
[Reply]
In58men 12:18 PM 05-07-2021
Got my first Moderna shot today, 2nd one in 4 weeks.

In and out at Costco.
[Reply]
loochy 12:57 PM 05-07-2021
Originally Posted by In58men:
In and out at Costco.
They put a burger joint inside Costco? Awesome!
[Reply]
MahomesMagic 12:52 PM 05-08-2021

GOOD - SWEDEN STOPS PCR TESTS AS COVID19 DIAGNOSIS.

Legal precedent set.

The Swedish Public Health Agency has developed national criteria for assessing freedom from infection in covid-19.

1-7https://t.co/9zr6rUd55w

— VeronicaM (@_V5M1000) May 8, 2021

[Reply]
O.city 07:38 AM 05-09-2021
Looks like a lot of the Asian countries are getting hit now

India is likely having 20k deaths per day. Maybe even closer to 40k. It’s awful
[Reply]
C3HIEF3S 08:46 AM 05-09-2021
Originally Posted by O.city:
Looks like a lot of the Asian countries are getting hit now

India is likely having 20k deaths per day. Maybe even closer to 40k. It’s awful
My coworker, who is in India right now with family, has lost 5 family members in the last month. It’s terrible.
[Reply]
Rain Man 09:24 AM 05-09-2021
Denver is no longer requiring restaurant workers to wear masks as long as 85 percent have been vaccinated.

https://www.thedenverchannel.com/new...-85-vaccinated
[Reply]
O.city 09:58 AM 05-09-2021
Originally Posted by C3HIEF3S:
My coworker, who is in India right now with family, has lost 5 family members in the last month. It’s terrible.
Yeah they’re just getting hit hard. The medical system has broken and it’s just getting worse
[Reply]
Chief Pagan 11:12 AM 05-09-2021
Originally Posted by O.city:
Yeah they’re just getting hit hard. The medical system has broken and it’s just getting worse
It’s been a hard argument to convince people that if we would have treated it like the flu and carried on as business like normal just how much worse it might have been especially in the early weeks and months when it wasn’t clear what exactly we were up against.

I think you can look at India and realize it could have been so much worse under a business as usual approach.

Sure their health care system isn’t as comparable but a little old flu isn’t supposed to be sending that many to the hospital in the first place. And they have a generally young population at that.

Luckily for us we managed to do enough to avoid a complete collapse of the hospital system and the vaccines are doing a fantastic job even against the new nastier variants.
[Reply]
notorious 11:36 AM 05-09-2021
Let's not compare the US to India when it comes to hygene and cleanliness.
[Reply]
O.city 11:53 AM 05-09-2021
Originally Posted by Chief Pagan:
It’s been a hard argument to convince people that if we would have treated it like the flu and carried on as business like normal just how much worse it might have been especially in the early weeks and months when it wasn’t clear what exactly we were up against.

I think you can look at India and realize it could have been so much worse under a business as usual approach.

Sure their health care system isn’t as comparable but a little old flu isn’t supposed to be sending that many to the hospital in the first place. And they have a generally young population at that.

Luckily for us we managed to do enough to avoid a complete collapse of the hospital system and the vaccines are doing a fantastic job even against the new nastier variants.
Really it was always about health system staying afloat. Once we figured out what we could do that would keep that afloat we would be ok. It would still be rough, but as long as it doesn’t collapse, we’ll get thru.

Now we’ve got enough vaccinated and natural immunity I think we’re going great.

We did a bunch of shit we didn’t need to and we didn’t do stuff that could have helped. It wasn’t perfect by any means but we’re gonna survive
[Reply]
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