Originally Posted by DaFace:
Right, but I can buy that opioids are BETTER purely for the level of pain relief. It's all the other side effects that make them less beneficial.
(I admittedly haven't ever had a significant pain issue nor used opioids though.)
Opioids absolutely are. The error is in stating that cannabinoids have no efficacy as analgesics. They do via multiple pathways that I listed. [Reply]
Originally Posted by patteeu:
Get bent, blowhard. I think you're projecting your own ignorance here. I hadn't taken you for a NORML-style miracle weed nut, but maybe you are. You certainly aren't going to show me any scientific studies demonstrating equivalent effectiveness so take your "scientific knowledge" handwaving somewhere else.
The fact that you are trying to equate me with someone who is lionizing marijuana shows how desperate and ignorant you are.
Regarding the rest of your braindead tripe, here are the scientific studies you asked for, but won't read and won't apologize for bullshitting about:
Mechanism of ActionDronabinol (synthetic delta-9-tetrahydrocannabinol [delta-9-THC]), an active cannabinoid and natural occurring component of Cannabis sativa L. (marijuana), activates cannabinoid receptors CB1 and CB2. Activation of the CB1 receptor produces marijuana-like effects on psyche and circulation, whereas activation of the CB2 receptor does not. Dronabinol has approximately equal affinity for the CB1 and CB2 receptors; however, efficacy is less at CB2 receptors. Activation of the cannabinoid system with dronabinol causes psychological effects that can be divided into 4 groups: affective (euphoria and easy laughter); sensory (increased perception of external stimuli and of the person’s own body); somatic (feeling of the body floating or sinking in the bed); and cognitive (distortion of time perception, memory lapses, difficulty in concentration). Most effects (eg, analgesia, appetite enhancement, muscle relaxation, hormonal actions) are mediated by central cannabinoid receptors (CB1), their distribution reflecting many of the medicinal benefits and adverse effects (Grotenhermen 2003).
Studies demonstrating their efficacy in treating various types of pain:
So, yeah. I'm projecting *my* ignorance. If you'd like, I could also shove a database of Clinical Pharmacology up your bloviating cloaca, you degenerate fucking cunt. [Reply]
Originally Posted by 'Hamas' Jenkins:
The fact that you are trying to equate me with someone who is lionizing marijuana shows how desperate and ignorant you are.
Regarding the rest of your braindead tripe, here are the scientific studies you asked for, but won't read and won't apologize for bullshitting about:
Mechanism of ActionDronabinol (synthetic delta-9-tetrahydrocannabinol [delta-9-THC]), an active cannabinoid and natural occurring component of Cannabis sativa L. (marijuana), activates cannabinoid receptors CB1 and CB2. Activation of the CB1 receptor produces marijuana-like effects on psyche and circulation, whereas activation of the CB2 receptor does not. Dronabinol has approximately equal affinity for the CB1 and CB2 receptors; however, efficacy is less at CB2 receptors. Activation of the cannabinoid system with dronabinol causes psychological effects that can be divided into 4 groups: affective (euphoria and easy laughter); sensory (increased perception of external stimuli and of the person’s own body); somatic (feeling of the body floating or sinking in the bed); and cognitive (distortion of time perception, memory lapses, difficulty in concentration). Most effects (eg, analgesia, appetite enhancement, muscle relaxation, hormonal actions) are mediated by central cannabinoid receptors (CB1), their distribution reflecting many of the medicinal benefits and adverse effects (Grotenhermen 2003).
Studies demonstrating their efficacy in treating various types of pain:
So, yeah. I'm projecting *my* ignorance. If you'd like, I could also shove a database of Clinical Pharmacology up your bloviating cloaca, you degenerate ****ing ****.
You also guaranteed that Trump had no interest in the presidency and would drop out before the primaries, iirc, so it's not like you've NEVER been wrong about something.
Originally Posted by listopencil:
That's not true.
Originally Posted by JASONSAUTO:
For sure. I'm sure I've experienced REAL pain in my life, marijuana definitely helps.
Originally Posted by listopencil:
I haven't used it myself. But I have very personal first hand experience with people who have, and it helped them quite a bit.
The issue here isn't whether it helps at all, it's whether it's as effective as narcotics. It isn't. [Reply]
Originally Posted by 'Hamas' Jenkins:
Opioids absolutely are.
Did you have to panic google this before you decided to agree with me?
Originally Posted by 'Hamas' Jenkins:
The error is in stating that cannabinoids have no efficacy as analgesics. They do via multiple pathways that I listed.
No, that wasn't the error, because that isn't what anyone said. To the extent that one part of one of my posts seemed to say that when isolated from it's context, I've already provided clarification. [Reply]
Originally Posted by 'Hamas' Jenkins:
The fact that you are trying to equate me with someone who is lionizing marijuana shows how desperate and ignorant you are.
Regarding the rest of your braindead tripe, here are the scientific studies you asked for, but won't read and won't apologize for bullshitting about:
Mechanism of ActionDronabinol (synthetic delta-9-tetrahydrocannabinol [delta-9-THC]), an active cannabinoid and natural occurring component of Cannabis sativa L. (marijuana), activates cannabinoid receptors CB1 and CB2. Activation of the CB1 receptor produces marijuana-like effects on psyche and circulation, whereas activation of the CB2 receptor does not. Dronabinol has approximately equal affinity for the CB1 and CB2 receptors; however, efficacy is less at CB2 receptors. Activation of the cannabinoid system with dronabinol causes psychological effects that can be divided into 4 groups: affective (euphoria and easy laughter); sensory (increased perception of external stimuli and of the person’s own body); somatic (feeling of the body floating or sinking in the bed); and cognitive (distortion of time perception, memory lapses, difficulty in concentration). Most effects (eg, analgesia, appetite enhancement, muscle relaxation, hormonal actions) are mediated by central cannabinoid receptors (CB1), their distribution reflecting many of the medicinal benefits and adverse effects (Grotenhermen 2003).
Studies demonstrating their efficacy in treating various types of pain:
So, yeah. I'm projecting *my* ignorance. If you'd like, I could also shove a database of Clinical Pharmacology up your bloviating cloaca, you degenerate fucking cunt.
I hope you have more schooling ahead of you before they let you start doling out drugs to real people.
None of those studies are responsive. For example, do you know what the word "adjunct" means? Google it if you don't. Quote the part of those studies where the favorable pain relief comparison to standard narcotics is discussed. [Reply]
